Korean Salmon DNA Injections: Understanding PN and PDRN Treatments

What people mean by "salmon DNA injections"

If you have researched Korean skin treatments, you have probably seen the phrase "salmon DNA injection". It sounds unusual, but it refers to a category of injectables made from purified DNA fragments, originally sourced from salmon. These ingredients are known as PN (polynucleotides) and PDRN (polydeoxyribonucleotide). They are widely used in Korean aesthetic medicine, and Rejuran is the most widely recognised brand in this category.

This guide explains what PN and PDRN are, how they are generally used, how they differ, and what to consider before trying them during a visit to Busan.

PN and PDRN in simple terms

Both PN and PDRN are made of DNA fragments that have been purified for medical use. The main difference is the length of the DNA chains and the way they are processed:

PDRN. Made of shorter DNA fragments. It has been used in medicine in some countries for wound healing and tissue repair, and in aesthetics it is often discussed in relation to skin recovery.
PN. Made of longer DNA chains, which gives the product a thicker, gel-like texture. In aesthetics, PN products are commonly used to support skin quality and texture.

In everyday conversation, both are often grouped together as "salmon DNA" treatments, but the products are not identical. A doctor can explain which type is being suggested and why.

How these treatments are generally used

In Korean clinics, PN and PDRN treatments are typically delivered through many fine injections into the superficial layers of the skin. They are commonly considered for:

Overall skin quality. Patients often seek a healthier-looking, more resilient complexion.
Fine lines and texture. They are frequently included in plans for uneven texture.
Thin or sensitive-looking skin. Some doctors use them for skin that appears fragile.
Support alongside other treatments. They are often discussed in combination with laser or energy-based treatments.

Laboratory and clinical research on polynucleotides is ongoing, and the evidence is generally described as encouraging but still developing. It is sensible to approach these treatments with realistic expectations. They are not a substitute for lifting procedures or fillers when there is significant sagging or volume loss.

What to expect from the treatment experience

A typical session involves cleansing, numbing cream, a waiting period and then the injections themselves. Common experiences include:

Mild stinging during injection. Numbing cream helps, but some sensation is normal.
Small raised bumps. PN products in particular often leave temporary bumps that settle within a short time.
Redness and mild swelling. These are common and usually short-lived.
Possible bruising. As with any injection, small bruises can occur.

If you have a fish or seafood allergy, or a history of reactions to injectables, tell the doctor before treatment. Pregnant or breastfeeding patients should consult a doctor and generally postpone cosmetic injections.

Salmon DNA treatments at Daybeau Clinic Seomyeon

At Daybeau Clinic Seomyeon, the PN-based treatment on our price list is Rejuran 2cc at 139,000 KRW, a first-visit price with VAT excluded (10% VAT added at payment), checked October 2026. Other PN or PDRN brands are not on the fixed list; you can ask during consultation which options are available and receive a quote if suitable.

Other skin boosters on the price list include Water Glow 2cc at 39,000 KRW and Exosome 2.5cc at 49,000 KRW, under the same terms. To learn more, see our Rejuran page or the broader skin boosters page.

Questions worth asking before treatment

Which product will be used? Ask for the brand name and whether it is PN or PDRN.
How much product is planned? Volume affects both the plan and the cost.
How many sessions might help? Many people consider a course, but the doctor will advise.
What downtime should I plan for? This matters if you have photos, flights or events coming up.

Frequently asked questions

Is salmon DNA actually from salmon?

The DNA fragments used in these products have traditionally been sourced from salmon and then highly purified for medical use. Ask the doctor about the specific product if you have concerns.